Modality vs. Morphology: A Framework for Time Series Classification for Biological Signals

May 18, 2026 ยท Grace Period ยท + Add venue

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Authors Jordan Tschida, Matthew Yohe, Edward Kane, Gavin Jager, Emma J. Reid, Tony G. Allen, Mark Story, Leanne Thompson, Joe Hoskins, Brandon Schreiber, Stan Seiferth, Scott Dolvin, David Cornett arXiv ID 2605.18483 Category cs.LG: Machine Learning Cross-listed cs.AI Citations 0
Abstract
Time series classification (TSC) of biological signals has progressed from handcrafted, modality-specific approaches to deep architectures capable of representing the diverse waveform structures of underlying physiological processes (i.e., morphology). This review introduces a unified morphology--modality framework that connects waveform structure to a methodological design, revealing how spikes, bursts, oscillations, slow drift, and hierarchical rhythms inform model design. By analyzing electroencephalography, electromyography, electrocardiography, photoplethysmography, and ocular modalities (electrooculography, pupillometry, eye-tracking), the review demonstrates how morphology determines preprocessing and modeling strategies. Integrating evidence across these biological signals, the framework reveals that morphology, not model class, most strongly determines performance and interpretability. This provides insight into why deep models succeed when their inductive biases align with underlying waveform dynamics. This review also identifies future work including morphological data augmentation and evaluation metrics to improve generalization. Together, these insights position morphology-aware modeling as a unifying principle for developing generalizable, interpretable, and physiologically meaningful TSC models across biological signals.
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